Gastroenterology Consultants,SC: Diseases of the GI tract PRIMARY BILIARY CIRRHOSIS [<<back | list all>>] Primary Biliary Cirrhosis (PBC) is a disease of the bile ducts inside the liver. The bile ducts become inflamed. The inflammation is chronic and causes scarring that eventually blocks and destroys the bile ducts. This interferes with proper drainage of bile so there is back up into the liver and the bloodstream. Eventually the liver becomes badly damaged and scarred. This is known as cirrhosis.